About the content
Fever in infants under 56 days demands careful evaluation to rule out serious infections. With evolving guidelines, geographic variations, and improved diagnostics, a structured approach is essential. This module provides key insights for managing febrile young infants in the ED. These patients are at high risk for conditions like bacterial meningitis and neonatal HSV. Understanding when to perform lumbar punctures, how to use risk stratification, and which tests to order helps deliver timely, effective care while avoiding unnecessary interventions. In just 20 minutes, this module will sharpen your ability to assess and manage febrile infants—ensuring fast, accurate care for this high-risk group.
What You Will Learn
- Understand the historical evolution of febrile young infant management, including geographic practice variations and low-risk criteria
- Describe key clinical features, diagnostic considerations, and treatment strategies for neonatal HSV
- Develop an evidence-based approach to testing and managing febrile young infants presenting to the ED
Acknowledgements
Created by
Children’s Hospital of Philadelphia
chop.edu

and
Pediatric Pandemic Network

The Pediatric Pandemic Network is supported in part by the Health Resources and Services Administration (HRSA) of the U.S. Department of Health and Human Services (HHS) as part of cooperative agreements U1IMC43532 and U1IMC45814 with 0 percent financed with nongovernmental sources. The content presented here is that of the authors and does not necessarily represent the official views of, nor an endorsement by HRSA, HHS, or the U.S. Government. For more information, visit HRSA.gov.
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You are free to download and share this work for noncommercial purposes, as long as you credit Children’s Hospital of Philadelphia for the original creation.
Enrollment options
Fever in infants under 56 days demands careful evaluation to rule out serious infections. With evolving guidelines, geographic variations, and improved diagnostics, a structured approach is essential. This module provides key insights for managing febrile young infants in the ED. These patients are at high risk for conditions like bacterial meningitis and neonatal HSV. Understanding when to perform lumbar punctures, how to use risk stratification, and which tests to order helps deliver timely, effective care while avoiding unnecessary interventions. In just 20 minutes, this module will sharpen your ability to assess and manage febrile infants—ensuring fast, accurate care for this high-risk group.
What You Will Learn
- Understand the historical evolution of febrile young infant management, including geographic practice variations and low-risk criteria
- Describe key clinical features, diagnostic considerations, and treatment strategies for neonatal HSV
- Develop an evidence-based approach to testing and managing febrile young infants presenting to the ED
