About the content
Neonates often show subtle symptoms that may signal serious conditions. Early recognition and a structured diagnostic approach are essential for timely, effective care. This module offers a clear framework for evaluating and managing neonatal emergencies in the ED. Treating sick neonates requires vigilance, rapid decision-making, and a broad differential. Many cases call for urgent transfer to a higher level of care. Using tools like the MISFITS mnemonic helps identify critical issues and guide escalation when needed. In just 20 minutes, this module will sharpen your ability to assess and manage neonatal emergencies—ensuring fast, informed care for these high-risk patients.
What You Will Learn
- Recognize that neonates often present with nonspecific symptoms, requiring a broad differential diagnosis
- Use the MISFITS mnemonic to systematically evaluate ill neonates and identify potential causes of illness
- Understand the importance of laboratory tests, imaging, and clinical findings in guiding diagnosis
- Identify when neonatal emergencies require transfer to a higher level of care
Acknowledgements
Created by
Children’s Hospital of Philadelphia
chop.edu

and
Pediatric Pandemic Network

The Pediatric Pandemic Network is supported in part by the Health Resources and Services Administration (HRSA) of the U.S. Department of Health and Human Services (HHS) as part of cooperative agreements U1IMC43532 and U1IMC45814 with 0 percent financed with nongovernmental sources. The content presented here is that of the authors and does not necessarily represent the official views of, nor an endorsement by HRSA, HHS, or the U.S. Government. For more information, visit HRSA.gov.
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Attribution-NonCommercial-NoDerivatives CC BY-NC-ND
You are free to download and share this work for noncommercial purposes, as long as you credit Children’s Hospital of Philadelphia for the original creation.
Enrollment options
Neonates often show subtle symptoms that may signal serious conditions. Early recognition and a structured diagnostic approach are essential for timely, effective care. This module offers a clear framework for evaluating and managing neonatal emergencies in the ED. Treating sick neonates requires vigilance, rapid decision-making, and a broad differential. Many cases call for urgent transfer to a higher level of care. Using tools like the MISFITS mnemonic helps identify critical issues and guide escalation when needed. In just 20 minutes, this module will sharpen your ability to assess and manage neonatal emergencies—ensuring fast, informed care for these high-risk patients.
What You Will Learn
- Recognize that neonates often present with nonspecific symptoms, requiring a broad differential diagnosis
- Use the MISFITS mnemonic to systematically evaluate ill neonates and identify potential causes of illness
- Understand the importance of laboratory tests, imaging, and clinical findings in guiding diagnosis
- Identify when neonatal emergencies require transfer to a higher level of care
